Calcipotriol

IUPAC name:(1R,3S,5E)-5-{2-[(1R,3aS,4Z,7aR)-1-[(2R,3E)-5-cyclopropyl-5-hydroxypent-3-en-2-yl]-7a-methyl-octahydro-1H-inden-4-ylidene]ethylidene}-4-methylidenecyclohyytyexane-1,3-diol

Trade name: Daivobex; Dovobex; Sorilux

CAS No.:112965-21-6

Molecular Formula: C₂₇H₄₀O₃

Molar mass: 412.605

Pharmacology action:

This product is similar to vitamin D analogues, the pharmacodynamic properties and vitamin D3 active metabolite of Calcitriol. In several in vitro models of this product and Calcitriol significantly inhibit cell proliferation and stimulate cell differentiation, such as both reduce the number of cells, total DNA content and radiation labeled thymidine incorporation into DNA, increase human keratinocytes and enhance the activity of the protein cross-linking enzyme, inhibit the proliferation and differentiation of epidermal cells.

Properties

Calcipotriol is a derivative of vitamin D, which combines with VD3 receptor on the cell surface and regulates the synthesis of DNA and keratin in cells. It can inhibit the excessive proliferation and induce the differentiation of skin cells (keratinocytes), so as to correct the abnormal proliferation and differentiation of psoriasis skin cells. At the same time, it can regulate the release of inflammatory factors, inhibit inflammatory infiltration and proliferation, and play an anti-inflammatory role. It has better therapeutic effect on psoriasis of scalp and other special parts.

CAS No.

112828-00-9

Formula

C27H40O3

Molecular Mass

412.60500

Exact Mass

412.29800

PSA

60.69000

Logp

5.09060

IUPAC

(1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(E,2R,5S)-5-cyclopropyl-5-hydroxypent-3-en-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol

Matter Classification

organic

Category

Density

1.12 g/cm3

Boiling Point

582ºC

Flash Point

250.6ºC

Appearance

solid

Acidity and Basicity