Calcitriol

IUPAC name: (1R,3S)-5-[2-[(1R,3aR,7aS)-1-[(2R)-6-hydroxy-6-methyl-heptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H- inden-4-ylidene]ethylidene]-4-methylidene-cyclohexane-1,3-diol

CAS No.: 32222-06-3

Molecular Formula: C₂₇H₄₄O₃

Molar weight: 416.64

Pharmacology action: This product is one of the most important metabolic products of vitamin D₃in human body. Under normal circumstances, Calcitriol is synthesized by the 25- hydroxy bile of its precursor. The daily physiological synthesis of the human body is about 0.5-1.0ug. During active periods of bone formation (such as growth or gestation period), the amount of it is also increased slightly. Calcitriol can promote intestinal absorption of calcium, and regulate bone calcification. For patients with severe renal failure, especially in long-term hemodialysis treatment, the synthesis of endogenous ossification of three alcohols decreased significantly and even completely stopped. The lack of three alcohol is the key to the formation of renal bone disease.