Valsartan

Product introduction:

Valsartan is a specific angiotensin Ⅱ (AT1) receptor antagonist. It is also another non skin AT1 receptor antagonist used in clinic after losartan. It plays a key role in regulating systemic blood pressure and maintaining electrolyte fluid balance. It selectively acts on AT1 receptor subtypes and blocks the binding of Ang Ⅱ to AT1 receptor (its specific antagonistic effect against AT1 receptor is about 20000 times greater than that of AT2 receptor), so as to inhibit vasoconstriction and aldosterone release and produce antihypertensive effect, but does not inhibit the aldosterone release caused by potassium ion (K +). The antihypertensive effect is superior to enalapril in the treatment of hypertension, mild to moderate essential hypertension, especially for secondary hypertension caused by kidney damage. It can significantly reduce proteinuria in hypertensive patients with normal diabetes or normal renal function, and has the protective effect of promoting uric acid and urinary sodium excretion. It is also suitable for reducing cardiovascular mortality in high-risk patients after heart attack (left ventricular failure or left ventricular dysfunction).

CAS：137862-53-4

Structural type:

Molecular formula:C₂₄H₂₉N₅O₃

Molecular weight: 435.52

Uses: antihypertensive drugs; Non peptide angiotensin Ⅱ AT1 receptor antagonist. For the treatment of hypertension.