Netoglitazone is an agent belonging to the glitazone class of antidiabetic agents with antihyperglycemic activity. Netoglitazone exerts both peroxisome proliferator-activated receptor (PPAR) alpha and gamma agonist activity. Netoglitazone decreases bone formation and increases marrow adipocyte formation in vivo.

4-Benzyl-2-[2-(Dimethylamino)Ethyl]Phthalazin-1-One

CAS:16188-61-7

Molecular Formula:C19H21N3O

Alias

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Talastina; Talastinum; 4-Benzyl-2-(2-Dimethylamino-Aethyl)-2H-Phthalazin-1-On; Talastinum [Inn-Latin]; Talastine; Talastina [Inn-Spanish]; 4-Benzyl-2-(2-Dimethylamino-Ethyl)-1-Oxo-1.2-Dihydro-Phthalazin; 4-Benzyl-2-(2-Dimethylamino-Ethyl)-2H-Phthalazin-1-One; Talastine (Inn); Unii-49Ab2Pa48B; 49Ab2Pa48B

Brief Introduction

Talastine is a member of phthalazines.

Temsirolimus

CAS:162635-04-3

Molecular Formula:C56H87NO16

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Ccl-779; Temsirolimus (~); Rapamycin 42-[3-Hydroxy-2-(Hydroxymethyl)-2-Methylpropanoate; Rapamycin 42-Ester With 3-Hydroxy-2-(Hydroxymethyl)-2-Methylpropionic Acid; (1R,2R,4S)-4-{(2R)-2-[(3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34As)-9,27-Dihydroxy-10,21-Dimethoxy-6,8,12,14,20,26-Hexamethyl-1,5,11,28,29-Pentaoxo-1,4,5,6,9,10,11,12,13,14,21,22,23,24,25,26,27,28,29,31,32,33,34,34A-Tetracosahydro-3H-23,27-Epoxypyrido[2,1-C][1,4]Oxazacyclohentriacontin-3-Yl]Propyl}-2-Methoxycyclohexyl 3-Hydroxy-2-(Hydroxymethyl)-2-Methylpropanoate; [14C]-Temsirolimus; 42-[3-Hydroxy-2-(Hydroxymethyl)-2-Methylpropanoate]Rapamycin; Rapamycin (42-[3-Hydroxy-2-(Hydroxymethyl)-2-Methylpropanoate]; Temsirolimus (Torisel); Temsirolimus (Cci-779,Torisel)

Brief Introduction

Teisirolimus, also known as sirolimus ester, is a targeted antitumor drug developed by Wyeth medicine (now incorporated into Pfizer medicine) for the treatment of progressive renal cancer. It is also the first targeted therapeutic drug for the treatment of renal cancer, and it is the only drug specifically inhibiting mTOR kinase on the market.

Gestrinone

CAS:16320-04-0

Molecular Formula:C21H24O2

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D-Gestrinone; Dimetriose; Gestrigone; Tridomose; Dimetrose; Nemestran

Brief Introduction

Gestrinone is a synthetic steroid hormone with strong anti estrogen, progesterone and moderate anti gonadotropin effects. It is one of the main drugs for the clinical treatment of endometriosis. According to clinical research, gestrinone can directly act on ectopic lesions, atrophy and degeneration, significantly reduce the score of patients, and significantly alleviate symptoms such as dysmenorrhea. At present, it has been considered that gestrinone plays its effect mainly by inducing apoptosis of ectopic endometrial cells, but the exact mechanism remains to be further explored.

N,N'-Bis[3,5-Bis[(E)-N-(Diaminomethylideneamino)-C-Methylcarbonimidoyl]Phenyl]Decanediamide,Tetrahydrochloride

CAS:164301-51-3

Molecular Formula:C34H56Cl4N18O2

Brief Introduction

Semapimodtetrahydrochloride (CNI-1493) is an inhibitor of pro-inflammatory cytokine production and can inhibit TNF- α、 IL-1 β And IL-6. Semapimodtetrahydrochloride inhibited the production of p38 MAPK and nitric oxide in macrophages. Semapimodtetrahydrochloride inhibits TLR4 Signal (IC50 ≈ 0.3 μ M)。 Semapimodtetrahydrochloride has a potential role in a variety of inflammatory and autoimmune diseases.

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