(+/-)-Methoxyverapamil,Hydrochloride; Gallopamil Hydrochloride; D 600 Hydrochloride; D600,Hcl; (+/-)-Methoxyverapamil Hcl; Gallopamil Hcl; Gallopamil; D600; (S)-Gallopamil; Procorum

Brief Introduction

Gallopamilhydrochloride is a methoxy derivative of verapamil and a phenylalkylamine calcium antagonist. Gallopamilhydrochloride inhibited acid secretion in a concentration dependent manner with an IC50 of 10.9 μ M。 Gallopamilhydrochloride is an effective antiarrhythmic and vasodilator.

Anidulafungin

CAS:166663-25-8

Molecular Formula:C58H73N7O17

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V-Echinocandin; Anidulafungin; Ver-002; Ecalta; Eraxis; Unii-9Hlm53094I

Brief Introduction

Anifenjing is an echinocandin antifungal drug, and its mechanism of action is the same as "caspofungin". It has antibacterial activity against Candida and Aspergillus, but not against Cryptococcus, Fusarium and trichosporum.

(4S,7S,10As)-5-Oxo-4-[[(2S)-3-Phenyl-2-Sulfanylpropanoyl]Amino]-2,3,4,7,8,9,10,10A-Octahydropyrido[2,1-B][1,3]Thiazepine-7-Carboxylic Acid

CAS:167305-00-2

Molecular Formula:C19H24N2O4S2

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Omapatrilat; Omapatrilat (Jan/Usan/Inn); Vanlev; Bms-186716; Bms 186716

Brief Introduction

Omapatrilat (INN) is a novel antihypertensive agent that inhibits both neutral endopeptidase (NEP) and angiotensin converting enzyme. NEP inhibition results in elevated natriuretic peptide levels, promoting natriuresis, diuresis, vasodilation, and reductions in preload and ventricular remodeling. This drug from Bristol-Myers Squibb was not approved by the U.S. Food and Drug Administration due to angioedema safety concerns. Omapatrilat angioedema was attributed to its dual mechanism of action, inhibiting both angiotensin converting enzyme (ACE), and neutral endopeptidase, both of these enzymes are responsible for the metabolism of bradykinin which causes vasodilation, angioedema, and airway obstruction.

Ornidazole

CAS:16773-42-5

Molecular Formula:C7H10ClN3O3

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1-(3-Chloro-2-Hydroxypropyl)-2-Methyl-5-Nitroimidazole; 1-Chloro-3-(2-Methyl-5-Nitro-1H-Imidazol-1-Yl)-2-Propanol; 1-Chloro-3-(2-Methyl-5-Nitro-1H-Imidazol-1-Yl)Propan-2-Ol; 1-Chloro-3-(2-Methyl-5-Nitroimidazol-1-Yl)Propan-2-Ol; Ornidazol A-(Chloromethyl)-2-Methyl-5-Nitro-1H-Imidazole-1-Ethanol; Alpha-(Chlormethyl)-2-Methyl-5-Nitro-Imidazol-1-Aethanol; Alpha-(Chloromethyl)-2-Methyl-5-Nitro-1H-Imidazole-1-Ethano; Ro7-0207

Brief Introduction

Ornidazole is the third generation of nitroimidazole, which has obvious antibacterial advantages over metronidazole and Tinidazole. The half-life of plasma elimination of ornidazole is 14.4 hours, which is higher than that of metronidazole (8.4 hours) and Tinidazole (12.7 hours). Therefore, ornidazole can reduce the times of taking medicine and is more convenient to use. It acts on the DNA of anaerobes, amoebas, Giardia and Trichomonas cells to break their helix structure or prevent their transcription and replication, resulting in the death of pathogenic bacteria. The peak plasma concentration was reached 2 hours after oral administration, and the bioavailability was about 90%.

Pantethine

CAS:16816-67-4

Molecular Formula:C22H42N4O8S2

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D-Pantethine; Dermorizin; Panthecin; Bis-(2-D-Pantothenoylamino-Ethyl)-Disulfide; Lipodel; Pantosin; Lbf Factor; Pantetina; Pantomin; Lbfdisulfide; Bis-(2-D-Pantothenoylamino-Aethyl)-Disulfid; Bis(N-Pantothenylamidoethyl) Disulfide,Lbf Factor,Pantethein Oxidized Form; Bis(Pantothenylamidoethyl) Disulfide; Pantethin

Brief Introduction

Pantethine (bis-pantethine or co-enzyme pantethine) is a dimeric form of pantetheine, which is produced from pantothenic acid (vitamin B5) by the addition of cysteamine. Pantethine is composed of two molecules of pantetheine linked by a bridging disulfide. Pantetheine is an intermediate in the production of Coenzyme A by the body. Most vitamin B5 supplements are in the form of calcium pantothenate, a salt of pantothenic acid, with doses in the range of 5 to 10mg/day. In contrast, pantethine is sold as a dietary supplement for lowering blood cholesterol and triglycerides at doses of 500 to 1200mg/day.

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