Pharmaceutical Raw Materials

Fluvastatin is a commonly used cholesterol lowering agent (statin) that is associated with mild, asymptomatic and self-limited serum aminotransferase elevations during therapy and rarely with clinically apparent acute liver injury.

Synephrine is a kind of bioactive substance, which is mainly extracted from Rutaceae plants such as aurantium aurantium, tangerine peel and green peel. It plays an important role in traditional Chinese medicine Fructus aurantii. It can strengthen heart, increase cardiac blood output, contract blood vessels, increase left ventricular pressure and arterial blood pressure due to high total peripheral vascular resistance, resist shock and lose weight, However, synephrine has been restricted in the United States, Canada and other countries in recent years due to its potential side effects of stimulating central nervous system and leading to cardiovascular disease.

Piperine is a kind of broad-spectrum anticonvulsant. It has a good antagonism to experimental electroconvulsive in mice. It has different degrees of antagonism to pentylenetetrazol, tetrandrine, strychnine, convulsion and audiogenic seizure caused by intracerebroventricular injection of curculine and glutamate. It is also effective for some types of epilepsy. The toxicity of piperine to flies was higher than that of pyrethrum. Piperine can be used as an additive in brandy to make it spicy. It can also be used as an insecticide. In addition, it is also the main anticonvulsant ingredient in Chinese prescription for epilepsy (white pepper and radish). It is used as spicy raw material in food industry and has bactericidal effect.

As a single quaternary ammonium cholinesterase reactivator, phosphine iodide can relieve the nicotine like symptoms of organophosphorus poisoning, rapidly relieve muscle fibrillation and bronchospasm, and is used in the rescue of acute organophosphorus poisoning. It has good effect on sarin, parathion, internal absorption of phosphorus, thiotep, malathion and parathion poisoning, but poor effect on tabun, dichlorvos and trichlorfon poisoning, There was no reactivation effect on cholinesterase inhibited by carbamate insecticides and diazinon, cyanophos, prochlorophos and octamethylphos. The quaternary ammonium group of the oxime compounds can tend to the cation site of the inactivated phosphorylcholinesterase bound by organophosphorus insecticides. Its nucleophilic group can directly combine with the phosphorylation group of cholinesterase and separate from the cholinesterase, so that the cholinesterase can recover its original state and reappear its activity. The reactivation effect on the aged cholinesterase inhibited by organophosphorus insecticides for more than 36 hours was very poor. It has no reactivation effect on cholinesterase inhibited by chronic organophosphorus pesticide poisoning. The effect of this product on the symptoms of nicotine like caused by organophosphorus insecticides is obvious, but the effect on the symptoms of muscarinic like is weak, and the effect on the symptoms of central nervous system is not obvious.

This product is a long-term drug β 2-adrenergic receptor agonist, with anti-inflammatory effect, is used in the treatment of asthma symptoms and chronic obstructive pulmonary disease symptoms.