Pharmaceutical Raw Materials

Indobufen is an anti platelet aggregation drug. It can selectively act on circulating platelets, block thrombosis, inhibit the release of platelet factors and play an anti platelet aggregation role. This inhibition is reversible, does not change plasma parameters, does not damage platelet function, and returns abnormal platelet function to normal. It can significantly improve the microcirculation parameters and walking distance of patients with peripheral vascular disease and intermittent claudication. It has the same effect as aspirin and dipyridamole in preventing obstruction after coronary artery shunt and femoral artery shunt; During hemodialysis, it can significantly reduce platelet deposits on the dialysis membrane. This product can also prevent secondary thrombosis after transient ischemic attack or mild stroke. Compared with similar drugs, indobufen inhibits platelet factor, and its anti platelet aggregation effect is 2 ~ 5 times that of salicylic acid, with slightly shorter bleeding time. Compared with ticlopidine, there was no significant difference in oral clinical efficacy, but indobufen showed good tolerance.

Trioxifene is a nonsteroidal selective estrogen receptor modulator (SERM) with potential antineoplastic activity. Trioxifene competes with estradiol in binding to estrogen receptor alpha (ER alpha), thereby inhibiting ER alpha-mediated signal transduction and gene expression. In addition, trioxifene exerts intrinsic estrogenic activity depending on the tissue. Clinical development of trioxifene has not been preceded due to its side effect profile and lack of increased efficacy over tamoxifen.

Cardiac selectivity β- Adrenergic receptor blockers have no endogenous sympathetic effect and have weak membrane stability. It is clinically used for the treatment of moderate hypertension.

Dihydropyridine calcium antagonists. It is used for hypertension, heart failure, ischemic heart disease, angina pectoris and atypical angina pectoris, especially for coronary heart disease complicated with hypertension.

For cerebral thrombosis, cerebral arteriosclerosis, sequelae of brain trauma, inner ear vertigo, coronary arteriosclerosis and diseases caused by poor peripheral circulation.