Pharmaceutical Raw Materials

Pazufloxacin is a kind of fluoroquinolones, which can inhibit the replication of bacterial DNA by inhibiting the activity of DNA helix topoisomerase IV. It is effective for general anaerobic bacteria, anaerobic gram positive bacteria and gram negative bacteria. It has strong antibacterial activity against Staphylococcus, enterobacter, Pseudomonas aeruginosa, various gram-negative bacteria, Bacteroides and Prevotella. This product has strong antibacterial activity against imipenem, cefazolin glycoside, ceftazidime resistant bacteria, intestinal bacterial flora, ampicillin resistant bacteria and Haemophilus influenzae. This product can kill Pseudomonas aeruginosa, Escherichia coli and Staphylococcus aureus. It is clinically used in respiratory tract, urinary tract, gynecology, surgery, otolaryngology, skin and soft tissue infections caused by sensitive bacteria.

Lomidixin is a histone deacetylase inhibitor, which can control the growth and induce apoptosis in neuroblastoma cells.

Kabalatin tartrate is the tartrate of kabalatin for Alzheimer's disease. Kabalatin is a derivative of physostigmine, which was developed by Novartis for the first time. The molecule has a phenyl carbamate structure. It is a carbamate brain selective cholinesterase inhibitor, which can inhibit acetylcholinesterase and butyrylcholinesterase at the same time, By delaying the degradation of acetylcholine released by cholinergic neurons and promoting cholinergic nerve conduction, we can improve the cognitive dysfunction mediated by cholinergic neurons, so as to improve the cognitive function of patients with Alzheimer's disease. The plasma protein binding capacity of kabalatine is weak, and it is easy to pass through the blood-brain barrier, so it has high brain selectivity. It can not only selectively affect the most vulnerable cerebral cortex and hippocampus, but also preferentially inhibit the dominant subtypes of ache in the brain, which can produce curative effect and reduce the peripheral cholinergic side effects. The half-life of cabalatine tartrate in vivo is short and the action time is long. Different from tacrine, this product has stronger inhibitory effect on G1 enzyme in hippocampus and cortex. Clinically, it is used for the treatment of mild and moderate Alzheimer's dementia, that is, suspected Alzheimer's disease or Alzheimer's disease.

Dapoxetine hydrochloride is a white to almost white powder, which is easily soluble in methanol and ethanol, slightly soluble in dichloroethane, and almost insoluble in water. Dapoxetine hydrochloride is a kind of bcsii compound, and its poor solubility is the key factor affecting the difference of clinical efficacy. There are many crystal forms of dapoxetine hydrochloride, and the solubility of different crystal forms is quite different, and there is a phenomenon of phase and transformation between crystal forms. Dapoxetine hydrochloride has similar pharmacological effects with other SSRIs. At first, dapoxetine was studied as an antidepressant, but different from other SSRIs, its pharmacokinetics showed that its oral absorption was fast, its half-life was short, and its excretion was fast, which made it a suitable drug for the treatment of premature ejaculation.

This product is a compound used in the research of mental diseases, such as schizophrenia, with dopamine D4 receptor selectivity and serotonin antagonism. It is suitable for acute schizophrenia, manic depression, climacteric psychosis, neurotic depression, etc.