Prothionamide

CAS：14222-60-7

Molecular formula: C9H12N2S

Molecular weight: 180.27

Structural type:

Physicochemical properties: yellow solid powder

Storage conditions: Low temperature storage, storage temperature is 2 ~ 8 ° C.

Application: Isonicotinamide is a derivative of isonicotinic acid. Its mechanism of action is unknown and may inhibit the synthesis of peptides. The effect of this product on Mycobacterium tuberculosis depends on the drug concentration at the infection site. It only has bacteriostatic effect at low concentration and bactericidal effect at high concentration. This product has partial cross resistance with ethylthioisonicotinamide.

Properties

As a derivative of isonicotinic acid, the mechanism of action of isonicotinic acid is unknown, which may inhibit peptide synthesis. The effect of this product on Mycobacterium tuberculosis depends on the drug concentration at the infected site. It only has antibacterial effect at low concentration, and bactericidal effect at high concentration. There is a partial cross resistance between this product and ethioisonicotinamide. Propisothamide is only effective against mycobacteria. This product is combined with other anti tuberculosis drugs in the treatment of tuberculosis by first-line drugs (such as streptomycin, isoniazid, rifampicin and ethambutol).

CAS No.

14222-60-7

Formula

C9H12N2S

Molecular Mass

180.27000

Exact Mass

180.07200

PSA

71.00000

Logp

2.36860