Allopurinol

Product introduction:

Allopurinol is white or off white crystalline powder, almost odorless. Very slightly soluble in water or ethanol. Insoluble in chloroform or ether; Soluble in sodium hydroxide or potassium hydroxide. Allopurinol and its metabolite oxypurinol can reduce the production of uric acid and reduce the content of uric acid in blood and urine below the solubility by inhibiting the activity of xanthine oxidase (the latter can convert hypoxanthine to xanthine and then xanthine to uric acid), so as to prevent the deposition of uric acid stones and contribute to the re dissolution of gout nodules and uric acid crystals.

CAS：315-30-0

Molecular formula: C₅H₄N₄O

Molecular weight: 136.11

Structural type:

Product purpose:

Allopurinol and its metabolite alloxanthine can inhibit xanthine oxidase, thus blocking the synthesis of uric acid, reducing the concentration of uric acid in blood and reducing the deposition of urate in bone, joint and kidney. It is clinically used for gout and gouty nephropathy. Pregnant women should use it with caution; Some patients may have skin rash, gastrointestinal reaction and liver and hematopoietic system damage, such as elevated aminotransferase and leukopenia; When combined with anticancer drug 6-mercaptopurine, the dose of 6-mercaptopurine should be reduced to 1 / 4 of the constant. Drink more water to excrete diuretic acid.