2'-((5-(4-Methylpiperazin-1-yl)Pyridin-2-yl)Amino)-7',8'-Dihydro-6'H-Spiro(Cyclohexane-1,9'-Pyrazino(1',2':1,5)Pyrrolo(2,3-d)Pyrimidin)-6'-one; G1T28; G1T-28; 4-[[5-(4-Methylpiperazin-1-yl)Pyridin-2-yl]Amino]Spiro[1,3,5,11-Tetrazatricyclo[7.4.0.02,7]Trideca-2,4,6,8-Tetraene-13,1'-Cyclohexane]-10-one

Brief Introduction

Trilaciclib (G1T28, G1T28-1) is a potent and selective reversible inhibitor of cyclin-dependent kinase 4 and 6 (CDK4/6). Trilaciclib inhibits CDK4/cyclin D1 and CDK6/cyclin D3 with IC50 values of 1 nM and 4 nM, respectively.

Bromazepam

CAS:1812-30-2

Molecular Formula:C14H10BrN3O

Alias

More Information

Bromaz; 7-Bromo-1,3-Dihydro-5-(2-Pyridyl)-2H-1,4-Benzodiazepin-2-one; 7-Bromo-5-Pyridin-2-yl-1,3-Dihydro-1,4-Benzodiazepin-2-one; Compedium; Durazanil; Lexotanil; Creosedin; Ultramidol; Lexilium

Brief Introduction

Controlled substance (depressant). Anxiolytic.

D13-9001

CAS:957471-96-4

Molecular Formula:C31H39N11O6S

Brief Introduction

D13-9001 is a potent AcrB (AcrAB-TolC efflux pump subunit) and MexB (MexAB-OprM efflux pump subunit) inhibitor with the KD values of 1.15 μM and 3.57 μM in E. coli and P. aeruginosa, respectively. D13-9001 exhibits antibiotic activities.

Ebselen

CAS:60940-34-3

Molecular Formula:C13H9NOSe

Alias

More Information

Ebseleno; Ebselene; Harmokisane; 2-Phenyl-1,2-Benzoselenazol-3-one; Ebselenum; 2-Phenylbenzo[d][1,2]Selenazol-3(2H)-one; 2-Phenyl-1,2-Benzisoselenazol-3(2H)-one

Brief Introduction

Ebselen is a organoselenium compound with anti-inflammatory, anti-oxidant and cytoprotective activity. Ebselen acts as a glutathione peroxidase mimetic and is thereby able to prevent cellular damage induced by reactive oxygen species (ROS). In addition, this agent inhibits the activity of a variety of enzymes including nitric oxide synthase (NOS), 5-lipoxygenase, cyclooxygenase, protein kinase C (PKC), NADPH oxidase and gastric H+/K+-ATPase. Furthermore, ebselen may be neuroprotective due to its ability to neutralize free radicals upon NMDA receptor activation thus, reducing lipoperoxidation mediated by glutamate-induced excitotoxicity.

Odevixibat

CAS:501692-44-0

Molecular Formula:C37H48N4O8S2

Brief Introduction

BYLVAY is an ileal bile acid transporter (IBAT) inhibitor indicated for the treatment of pruritus in patients with progressive familial intrahepatic cholestasis (PFIC) of 3 months and older.

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