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CAS:923564-51-6
Molecular Formula:C47H55ClF3N5O6S3
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Navitoclax; ABT 263; ABT263; (R)-4-(4-((4'-Chloro-4,4-Dimethyl-3,4,5,6-Tetrahydro-[1,1'-Biphenyl]-2-yl)Methyl)Piperazin-1-yl)-N-((4-((4-Morpholino-1-(Phenylthio)Butan-2-yl)Amino)-3-((Trifluoromethyl)Sulfonyl)Phenyl)Sulfonyl)Benzamide; 4-[4-[[2-(4-Chlorophenyl)-5,5-Dimethyl-1-Cyclohexen-1-yl]Methyl]-1-Piperazinyl]-N-[[4-[[(1R)-3-(4-Morpholinyl)-1-[(Phenylthio)Methyl]Propyl]Amino]-3-[(Trifluoromethyl)Sulfonyl]Phenyl]Sulfonyl]Benzamide; 4-[4-[[2-(4-Chlorophenyl)-5,5-Dimethylcyclohexen-1-yl]Methyl]Piperazin-1-yl]-N-[4-[[(2R)-4-Morpholin-4-yl-1-Phenylsulfanylbutan-2-yl]Amino]-3-(Trifluoromethylsulfonyl)Phenyl]Sulfonylbenzamide; (R)-4-(4-((2-(4-Chlorophenyl)-5,5-Dimethylcyclohex-1-enyl)Methyl)Piperazin-1-yl)-N-(4-(4-Morpholino-1-(Phenylthio)Butan-2-Ylamino)-3-(Trifluoromethylsulfonyl)p; (R)-4-(4-((2-(4-Chlorophenyl)-5,5-Dimethylcyclohex-1-enyl)Methyl)Piperazin-1-yl)-N-(4-(4-Morpholino-1-(Phenylthio)Butan-2-Ylamino)-3-(Trifluoromethylsulfonyl)Phenylsulfonyl)Benzamide; 4-(4-{[2-(4-Chlorophenyl)-5,5-Dimethylcyclohex-1-en-1-yl]Methyl}Piperazin-1-yl)-N-({4-({(1R)-3-Morpholin-4-yl-1-[(Phenylsulfanyl)Methyl]Propyl}Amino)-3-[(Trifluoromethyl)Sulfonyl]Phenyl}Sulfonyl)Benzamide; 4-(4-{[2-(4-Chlorophenyl)-5,5-Dimethylcyclohex-1-En-1-Yl]Methyl}Piperazin-1-Yl)-N-[(4-{[(2r)-4-(Morpholin-4-Yl)-1-(Phenylsulfanyl)Butan-2-Yl]Amino}-3-[(Trifluoromethyl)Sulfonyl]Phenyl)Sulfonyl]Benzamide; Navitoclaxum; C47H55ClF3N5O6S3; 4-(4-((2-(4-Chlorophenyl)-5,5-Dimethylcyclohex-1-EN-1-YL)Methyl)Piperazin-1-YL)-N-((4-(((2R)-4-(Morpholin-4-YL)-1-(Phenylsulfanyl)Butan-2-YL)Amino)-3-((Trifluoromethyl)Sulfonyl)Phenyl)Sulfonyl)Benzamide; ABT-263,Navitoclax; ABT-263 In Bulk; Navitoclax, ABT-263; ABT-263 - Navitoclax; 4-[4-[[2-(4-Chlorophenyl)-5,5-Dimethyl-1-Cyclohexen-1-yl]Methyl]-1-Piperazinyl]-N-[[4-[[(1R)-3-(4-mo; 4-[4-[[2-(4-Chlorophenyl)-5,5-Dimethyl-Cyclohexen-1-yl]Methyl]Piperazin-1-yl]-N-[4-[[(1R)-3-Morpholino-1-(Phenylsulfanylmethyl)Propyl]Amino]-3-(Trifluoromethylsulfonyl)Phenyl]Sulfonyl-Benzamide; 4-[4-[[2-(4-Chlorophenyl)-5,5-Dimet; (R)-4-(4-((4-Chloro-4,4-Dimethyl-3,4,5,6-Tetrahydro-[1,1-Biphenyl]-2-yl)Methyl)Piperazin-1-yl)-N-((4-((4-Morpholino-1-(Phenylthio)Butan-2-yl)Amino)-3-((Trifluoromethyl)Sulfonyl)Phenyl)Sulfonyl)Benzamide; 4-(4-((2-(4-Chlorophenyl)-5,5-Dimethylcyclohex-1-EN-1-YL)Methyl)Piperazin-1-YL)-N-(4-(((2R)-4-(Morpholin-4-YL)-1-(Phenylsulfanyl)Butan-2-YL)Amino)-3-(Trifluoromethanesulfonyl)Benzenesulfonyl)Benzamide; 4-(4-{[2-(4-Chlorophenyl)-5,5-Dimethylcyclohex-1-en-1-yl]Methyl}Piperazin-1-yl)-N-({4-({(1R)-3-(Morpholin-4-yl)-1-[(Phenylsulfanyl)Methyl]Propyl}Amino)-3-[(Trifluoromethyl)Sulfonyl]Phenyl}Sulfonyl)Benzamide; 4-[4-[[2-(4-Chlorophenyl)-5,5-Dimethyl-1-Cyclohexen-1-yl]Methyl]-1-Piperazinyl]-N-[[4-[[(1R)-3-(4-Morpholinyl)-1-[(Phenylthio)Methyl]Propyl]Amino]-3-[(Trifluoromethyl)Sulfonyl]Phenyl]Sulfonyl]Benzamide;ABT 263;Benzamide, 4-(4-((2-(4-Chlorophenyl)-5,5-dime; 4-{4-[(4'-Chloro-4,4-Dimethyl-3,4,5,6-Tetrahydro[Biphenyl]-2-yl)Methyl]Piperazin-1-yl}-N-[(4-{[(2R)-4-(Morpholin-4-yl)-1-(Phenylsulfanyl)Butan-2-yl]Amino}-3-[(Trifluoromethyl)Sulfonyl]Phenyl)Sulfonyl]Benzamide; Benzamide, 4-(4-((2-(4-Chlorophenyl)-5,5-Dimethyl-1-Cyclohexen-1-YL)Methyl)-1- Piperazinyl)-N-((4-(((1R)-3-(4-Morpholinyl)-1-((Phenylthio)Methyl)Propyl)Amino)-3-((Trifluoromethyl)Sulfonyl)Phenyl)Sulfonyl)-; Benzamide, 4-(4-((2-(4-Chlorophenyl)-5,5-Dimethyl-1-Cyclohexen-1-yl)Methyl)-1-Piperazinyl)-N-((4-(((1R)-3-(4-Morpholinyl)-1-((Phenylthio)Methyl)Propyl)Amino)-3-((Trifluoromethyl)Sulfonyl)Phenyl)Sulfonyl)-; N-(4-{4-[2-(4-Chlorophenyl)-5,5-Dimethyl-Cyclohex-1-Enylmethyl]-Piperazin-1-yl}-Benzoyl)-4-((r)-3-Morpholin-4-yl-1-Phenylsulfanylmethyl-Propylamino)-3-Trifluoromethanesulfonyl-Benzenesulfonamide
Brief Introduction
ABT 263 is a new inhibitor of the anti-apoptotic BCL-2 protein; a promising new drug against cancer. It is a potent Bcl-2 family inhibitor.
CAS:17374-26-4
Molecular Formula:C6HBr4N3
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4,5,6,7-Tetrabromobenzotriazole; 4,5,6,7-Tetrabromo-2H-Benzotriazole; 4,5,6,7-Tetrabromo-2-Azabenzimidazole 4,5,6,7-Tetrabromobenzotriazole; 4,5,6,7-Tetrabromo-2-Azabenzimidazole,4,5,6,7-Tetrabromobenzotriazole; TBB
Brief Introduction
TBB is one of the most selective protein kinase inhibitors known, and when tested against a panel of 33 serine/threonine and tyrosine protein kinases, only three exhibited moderate inhibition by TBB, with Ki values one to two orders of magnitude higher than that for CK2.
CAS:2244035-16-1
Molecular Formula:C26H24ClNO3
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CS-0089777; (E)-3-[6-[1-(2-Chloro-6-Cyclopropylphenyl)Ethoxy]-4-Cyclopropylquinolin-3-yl]prop-2-Enoic acid; 2-Propenoic acid, 3-[6-[1-(2-Chloro-6-Cyclopropylphenyl)Ethoxy]-4-Cyclopropyl-3-Quinolinyl]-; HY-125176
Brief Introduction
G907 is a selective small-molecule antagonist of ATP-binding cassette (ABC) transporter, MsbA. It inhibits purified E. coli MsbA in amphipols with an IC50 of 18 nM. G907 traps MsbA in an inward-facing
CAS:1207753-03-4
Molecular Formula:C44H67N5O4
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MK 3118; MK-3118; SCY 078; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-Amino-2,3,3-Trimethylbutyl]oxy]-8-[(1R)-1,2-Dimethylpropyl]-14-[5-(4-Pyridinyl)-1H-1,2,4-Triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-Dodecahydro-1,6a,8,10a-Tetramethyl-4H-1,4a-Propano-2H-Phenanthro[1,2-c]Pyran-7-Carboxylic acid; Ibrexafungerp; Ibrexafungerp(SCY-078)
Brief Introduction
Antifungal (SCY-078), a novel oral and intravenous (IV) drug for the treatment of severe and life-threatening invasive fungal infections in humans.
CAS:1374743-00-6
Molecular Formula:C24H30N8O
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2'-((5-(4-Methylpiperazin-1-yl)Pyridin-2-yl)Amino)-7',8'-Dihydro-6'H-Spiro(Cyclohexane-1,9'-Pyrazino(1',2':1,5)Pyrrolo(2,3-d)Pyrimidin)-6'-one; G1T28; G1T-28; 4-[[5-(4-Methylpiperazin-1-yl)Pyridin-2-yl]Amino]Spiro[1,3,5,11-Tetrazatricyclo[7.4.0.02,7]Trideca-2,4,6,8-Tetraene-13,1'-Cyclohexane]-10-one
Brief Introduction
Trilaciclib (G1T28, G1T28-1) is a potent and selective reversible inhibitor of cyclin-dependent kinase 4 and 6 (CDK4/6). Trilaciclib inhibits CDK4/cyclin D1 and CDK6/cyclin D3 with IC50 values of 1 nM and 4 nM, respectively.
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