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CAS:1889284-33-6
Molecular Formula:C29H27F5N6O4
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Spiro[Imidazolidine-4,1'-[1H]Indene]-1-Acetamide,3'-Fluoro-N-[(4-Fluorophenyl)Methyl]-2',3'-Dihydro-5'-[1-Chemicalbook[2-(Methylamino)-2-Oxoethyl]-1H-Pyrazol-4-yl]-2,5-Dioxo-N-[(1S)-2,2,2-Trifluoro-1-Methylethyl]-,(1'S,3'R)-; CBP/p300-IN-5; iP300w
Brief Introduction
iP300w is a potent p300/CBP inhibitor. iP300w inhibits p300-mediated H3K9 acetylation (IC50 = 33 nM). The cytotoxicity of DUX4 and overexpression of DUX4 target genes are inhibited by iP300w in vitro. In addition, the compound inhibits DUX4-mediated transcription in an animal model of facioscapulohumeral muscular dystrophy (FSHD). iP300w reduces viability and inhibits proliferation of CIC-DUX4 sarcoma (CDS) cells in vitro but not pancreatic or colorectal cancer cell lines. The compound suppresses tumor growth in a mouse CDS xenograft model.
CAS:1192500-31-4
Molecular Formula:C7H11N3O6S
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(E)-7-Fluoro-3-Methylhept-4-en-2-one; (2S,5R)-7-Oxo-6-(Sulfooxy)-1,6-Diazabicyclo[3.2.1]Octane-2-Carbox Amide; 4-Hepten-2-one,7-Fluoro-3-Methyl-,(E); Trans-7-Fluoro-3-Methyl-4-Hepten-2-one; Trans-7-oxo-6-(Sulphooxy)-1,6-Diazabicyclo[3.2.1]Octane-2-Carboxamide; Avibactam free acid; NXL104; AVE-1330A free acid
Brief Introduction
Avibactam is a member of the class of azabicycloalkanes that is (2S,5R)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamide in which the amino hydrogen at position 6 is replaced by a sulfooxy group. Used (in the form of its sodium salt) in combination with ceftazidime pentahydrate for the treatment of complicated urinary tract infections including pyelonephritis. It has a role as an antibacterial drug, an antimicrobial agent and an EC 3.5.2.6 (beta-lactamase) inhibitor. It is a monocarboxylic acid amide, a member of ureas, an azabicycloalkane and a hydroxylamine O-sulfonic acid. It is a conjugate acid of an avibactam(1-).
CAS:2310299-91-1
Molecular Formula:C20H27N5O11S
CAS:2189684-44-2
Molecular Formula:C39H32ClF10N7O5S2
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1H-Cyclopropa[3,4]Cyclopenta[1,2]Pyrazole-1-Acetamide,N-[(1S)-1-[3-[4-Chloro-3-[(Methylsulfonyl)Amino]-1-(2,2,2-Trifluoroethyl)-1H-Indazol-7-yl]-6-[3-Methyl-3-(Methylsulfonyl)-1-Butyn-1-yl]-2-Pyridinyl]-2-(3,5-Difluorophenyl)Ethyl]-5,5-Difluoro-3b,4,4a,5-Tetrahydro-3-(Trifluoromethyl)-,(3bS,4aR)-; GS-6207; GS-HIV; GS-CA1; GS-CA2; GS-714207; N-[(1S)-1-[3-[4-Chloro-3-(Methanesulfonamido)-1-(2,2,2-Trifluoroethyl)Indazol-7-yl]-6-(3-Methyl-3-Methylsulfonylbut-1-ynyl)Pyridin-2-yl]-2-(3,5-Difluorophenyl)Ethyl]-2-[(2S,4R)-5,5-Difluoro-9-(Trifluoromethyl)-7,8-Diazatricyclo[4.3.0.02,4]nona-1(6),8-dien-7-yl]Acetamide; N-((S)-1-(3-(4-Chloro-3-(Methylsulfonamido)-1-(2,2,2-Trifluoroethyl)-1H-Indazol-7-yl)-6-(3-Methyl-3-(Methylsulfonyl)but-1-yn-1-yl)Pyridin-2-yl)-2-(3,5-Difluorophenyl)Ethyl)-2-((3bS,4aR)-5,5-Difluoro-3-(Trifluoromethyl)-3b,4,4a,5-Tetrahydro-1H-Cyclopropa[3,4]Cyclopenta[1,2-c]Pyrazol-1-yl)Acetamide; N-[(1S)-1-(3-{4-Chloro-3-[(Methylsulfonyl)Amino]-1-(2,2,2-Trifluoroethyl)-1H-Indazol-7-yl}-6-[3-Methyl-3-(Methylsulfonyl)but-1-yn-1-yl]Pyridin-2-yl)-2-(3,5-Difluorophenyl)Ethyl]-2-[(3bS,4aR)-5,5-Difluoro-3-(Trifluoromethyl)-3b,4,4a,5-Tetrahydro-1H-Cyclopropa[3,4]Cyclopenta[1,2-c]Pyrazol-1-yl]Acetamide; QNG; N-[(1S)-1-[3-[4-Chloro-3-(Methanesulfonamido)-1-(2,2,2-Trifluoroethyl)Indazol-7-yl]-6-(3-Methyl-3-Methylsulfonyl-but-1-ynyl)-2-Pyridyl]-2-(3,5-Difluorophenyl)Ethyl]-2-[Difluoro(Trifluoromethyl)[?]yl]Acetamide
Brief Introduction
Lenacapavir is an HIV-1 capsid inhibitor. In MT-4 cells, gs-6207 has anti HIV activity with an EC50 of 100 PM, and in peripheral blood mononuclear cells, the average EC50 for 23 HIV-1 clinical isolates from different subtypes is 50 PM (20 – 160 PM).
CAS:2097132-94-8
Molecular Formula:C27H32FN9O2
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BLU-667; Pralsetinib free base; cis-Pralsetinib; Blu667; Trans-Pralsetinib; N-[(1S)-1-[6-(4-Fluoropyrazol-1-yl)Pyridin-3-yl]Ethyl]-1-Methoxy-4-[4-Methyl-6-[(5-Methyl-1H-Pyrazol-3-yl)Amino]Pyrimidin-2-yl]Cyclohexane-1-Carboxamide; cis-N-{(1S)-1-[6-(4-Fluoro-1H-Pyrazol-1-yl)Pyridin-3-yl]Ethyl}-1-Methoxy-4-{4-Methyl-6-[(5-Methyl-1H-Pyrazol-3-yl)Amino]Pyrimidin-2-yl}Cyclohexane-1-Carboxamide; Gavreto; (1s,4R)-N-((S)-1-(6-(4-Fluoro-1H-Pyrazol-1-yl)Pyridin-3-yl)Ethyl)-1-Methoxy-4-(4-Methyl-6-((5-Methyl-1H-Pyrazol-3-yl)Amino)Pyrimidin-2-yl)Cyclohexane-1-Carboxamide; (1r,4S)-N-((S)-1-(6-(4-Fluoro-1H-Pyrazol-1-yl)Pyridin-3-yl)Ethyl)-1-Methoxy-4-(4-Methyl-6-((5-Methyl-1H-Pyrazol-3-yl)Amino)Pyrimidin-2-yl)Cyclohexane-1-Carboxamide
Brief Introduction
Blu667 is a highly effective and selective RET inhibitor with an IC50 value of 0.4 nm for inhibiting wild-type RET kinase.
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