Voreloxin (SNS-595; Vosaroxin; AG 7352) is a novel topoisomerase II inhibitor, which can induce DNA double strand break, block G2 phase and finally apoptosis.

6-Chloro-1,1-Dioxo-3-(2,2,2-Trifluoroethylsulfanylmethyl)-3,4-Dihydro-2H-1λ<Sup>6</Sup>,2,4-Benzothiadiazine-7-Sulfonamide

CAS:1764-85-8

Molecular Formula:C10H11ClF3N3O4S3

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Epithiazide [Usan]; Epithiazide; Epitizide; Epitizidum; P 2105; Epitizid

Brief Introduction

Epitizide is a diuretic. It is often combined with triamterene.

2,2-Bis(4-Hydroxyphenyl)-4H-1,4-Benzoxazin-3-One

CAS:17692-24-9

Molecular Formula:C20H15NO4

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La271A; Bisoxatine; Einecs 241-681-6; Bisoxatin; Bisoxatina; Bisoxatinum; Unii-7C75N0L7Fp; 7C75N0L7Fp

Brief Introduction

Bisoxatin is a stimulant laxative which increases peristalsis and inhibits absorbtion of water and ions in the intestine. It is marketed in Belgium under the tradename Wylaxine and used for the treatment of constipation and for preparation of the colon for surgical procedures.

(2S)-2-(4,6-Dimethylpyrimidin-2-Yl)Oxy-3-Methoxy-3,3-Diphenylpropanoic Acid

CAS:177036-94-1

Molecular Formula:C22H22N2O4

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Letairis; (S)-2-(4,6-Dimethylpyrimidin-2-Yloxy)-3-Methoxy-3,3-Diphenylpropanoic Acid; Unii-Hw6Nv07Qec; Ambrisentan; Volibris; Bsf 208075

Brief Introduction

Ansentan is a selective antagonist of ETA. Blocking ETA activation by ET-1 reduces vasoconstriction and potential smooth muscle cell proliferation involved in the pathogenesis of pulmonary hypertension. Increase pulmonary artery blood flow. Ansentan is a highly selective antagonist of ETA, which retains the production of ETB mediated vasodilators nitric oxide and prostacyclin.

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