Casopitant is a centrally-acting neurokinin 1 (NK1) receptor antagonist with antidepressant and antiemetic activities. Casopitant competitively binds to and blocks the activity of the NK-receptor, thereby inhibiting NK1-receptor binding of the endogenous tachykinin neuropeptide substance P (SP), which may result in antiemetic effects. SP is found in neurons of vagal afferent fibers innervating the brain-stem nucleus tractus solitarii and the area postrema, which contains the chemoreceptor trigger zone (CTZ), and may be elevated in response to chemotherapy. The NK-receptor is a G-protein receptor coupled to the inositol phosphate signal-transduction pathway and is found in both the nucleus tractus solitarii and the area postrema.

Tocainide

MSDS

CAS:41708-72-9

Molecular Formula:C11H16N2O

Alias

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R/S-Tocainide; 2-Amino-2',6'-Propionoxylidide; 6'-Propionoxylidide,2-Amino-2; Alanyl-2,6-Xylidide; Tonocard; Tocainidum; 2-Amino-N-(2,6-Dimethylphenyl)Propanamide

Brief Introduction

Tocainide (Tonocard) is a class Ib antiarrhythmic agent. It is no longer sold in the United States.

Bezafibrate

MSDS

CAS:41859-67-0

Molecular Formula:C19H20ClNO4

Alias

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Difaterol; Bezafibric Acid; Bezalip; Bezafibrato; 2-[4-[2-(4-Chlorobenzamido)Ethyl]Phenoxy]-2-Methylpropanoic Acid; Cedur; Bezafibrate; 2-[4-[2-(4-Chlorobenzamido)Ethyl]Phenoxy]Isobutyric Acid; Befizal; Bezafibrat; Bezatol; Bf-759

Brief Introduction

Bezafibrate is a kind of lipid regulating drug derived from clofibrate. Its hypolipidemic effect has two mechanisms. One is that it increases the activity of lipoprotein lipase and liver lipase, promotes the catabolism of very low density lipoprotein, and reduces the level of blood triglyceride. Secondly, this product can reduce the secretion of very low density lipoprotein.

3-(4-(Trifluoromethyl)Phenyl)Acrylaldehyde

MSDS

CAS:41917-83-3

Molecular Formula:C10H7F3O

Alias

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(E)-3-[4-(Trifluoromethyl)Phenyl]Prop-2-Enal

Brief Introduction

This product can be used as pharmaceutical intermediate.

5-(3-Methylphenoxy)-1H-Pyrimidin-2-One

MSDS

CAS:41964-07-2

Molecular Formula:C11H10N2O2

Alias

More Information

Qcr-285; Tolimidone (Usan); 5-(M-Tolyloxy)-2-(1H)-Pyrimidinon; Tolimidone; Unii-Mu3Jd8E9Is; 5-M-Tolyloxy-1H-Pyrimidin-2-One; 5-(3-Methylphenoxy)-2(1H)-Pyrimidinone; Tolimidone [Usan:Inn]; 5-(3-Methylphenoxy)- 2(1H)-Pyrimidinone Cp 26154

Brief Introduction

Tolimidone can be used as mother nucleus to prepare a series of bioactive substances.

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