Qcr-285; Tolimidone (Usan); 5-(M-Tolyloxy)-2-(1H)-Pyrimidinon; Tolimidone; Unii-Mu3Jd8E9Is; 5-M-Tolyloxy-1H-Pyrimidin-2-One; 5-(3-Methylphenoxy)-2(1H)-Pyrimidinone; Tolimidone [Usan:Inn]; 5-(3-Methylphenoxy)- 2(1H)-Pyrimidinone Cp 26154

Brief Introduction

Tolimidone can be used as mother nucleus to prepare a series of bioactive substances.

N-(2-Chloro-4-Methylphenyl)-4,5-Dihydro-1H-Imidazol-2-Amine

MSDS

CAS:4201-22-3

Molecular Formula:C10H12ClN3

Alias

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Tolonidina; St-375; Euctan; Tolonidine; Tolonidinum; Tolonidine [Inn:Dcf]; Unii-I4O795Q03O

Brief Introduction

Tolonidine is a derivative of imidazoline. Tolonidine is effective orally and has antihypertensive and antihypertensive effects.

Clonidine (Amino Form)

MSDS

CAS:4205-90-7

Molecular Formula:C9H9Cl2N3

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N-(2,6-Dichlorophenyl)-4,5-Dihydro-1H-Imidazol-2-Amine; 2-(2',6'-Dichlorophenylamino)-Imidazoline; [14C]-Clonidine; [3H]-Clonidine; Catapres-Tts; Clonidine; Catarpres; Adesipress; Duraclon; Clonidin; Catarpresan; Catapressan; Catapresan; Chlornidinum

Brief Introduction

Clonidine (cataples) is a drug originally approved for the treatment of hypertension. However, because clonidine has a sedative effect, it has been found that clonidine can help people with ADHD, such as hyperactivity, impulsivity, aggression, excessive excitement and sleep difficulties.

(2R,3S)-5-[3-(Tert-Butylamino)-2-Hydroxypropoxy]-1,2,3,4-Tetrahydronaphthalene-2,3-Diol

MSDS

CAS:42200-33-9

Molecular Formula:C17H27NO4

Alias

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Nadololum [Inn-Latin]; Corgaretic; Nadolol; Solgol; (2R,3S)-5-(3-(Tert-Butylamino)-2-Hydroxypropoxy)-1,2,3,4-Tetrahydronaphthalene-2,3-Diol; Anabet; Corgard; 5-[3-[(1,1-Dimethylethyl)-Amino]-2-Hydroxypropoxy]-1,2,3,4-Tetrahydro-2,3-Cis-Naphthalenediol; 5-[3-(Tert-Butylamino)-2-Oxopropoxy]-1,2,3,4-Tetrahydronaphthalene-2,3-Diol; Nadic; [14C]-Nadolol; Nadololum; 1-Tert.-Butylamino-3-(1,2,3,4-Tetrahydro-2,3-Dihydroxy-5-Napthyloxy)-2-Propanol

Brief Introduction

Nadolol (corgard, solgol, anabet, sq11725) is a non selective β- Adrenergic receptor antagonists have antihypertensive and antiarrhythmic activities.

Oxilorphan

MSDS

CAS:42281-59-4

Molecular Formula:C20H27NO2

Alias

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3,14-Dihydroxy-N-Cyclopropylmethylmorphinan; Oxilorfano [Inn-Spanish]; (-)-17-Cyclopropylmethylmorphinan-3,4-Diol; (L)-Bc-2605; Bristol Laboratories Bc 2605; Levo-Bc-2605; Einecs 255-749-8; Unii-9Y9J2J74To; 9Y9J2J74To

Brief Introduction

Oxilorphan (INN, USAN) (developmental code name L-BC-2605) is an opioid antagonist of the morphinan family that was never marketed. It acts as a μ-opioid receptor (MOR) antagonist but a κ-opioid receptor (KOR) partial agonist, and has similar effects to naloxone and around the same potency as an MOR antagonist. Oxilorphan has some weak partial agonist actions at the MOR (with miosis, nausea, dizziness, and some euphoria observed) and can produce hallucinogenic/dissociative effects at sufficient doses, indicative of KOR activation. It was trialed for the treatment of opioid addiction, but was not developed commercially. The KOR agonist effects of oxilorphan are associated with dysphoria, which combined with its hallucinogenic effects, serve to limit its clinical usefulness; indeed, many patients who experienced these side effects refused to take additional doses in clinical trials.

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