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N-[4-[2-Hydroxy-3-(Propan-2-Ylamino)Propoxy]Phenyl]Acetamide; Rac Practolol; Dalzic; Eraldin; Teranol
Brief Introduction
Practolol is an effective and selective method β 1 adrenergic receptor antagonist. Practolol can be used to study arrhythmias.
CAS:66734-13-2
Molecular Formula:C28H37ClO7
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Almeta; Alclometasonedipropionate,Usp; Delonal; Alclovate; Alclometasone-17,21-Dipropionate; Ddlonal; Aclovate; Modrasone; Aclosone; Vitra
Brief Introduction
Local use of corticosteroids has strong local anti-inflammatory, antipruritic and vasoconstrictive effects. For eczema, atopic dermatitis, psoriasis and other skin diseases.
CAS:66827-12-1
Molecular Formula:CH11AlMg3O12
Brief Introduction
Aluminum magnesium addition does not play a therapeutic role simply by neutralizing gastric acid. It inhibits the guaranteed hydrolysis of pepsin by reducing acid ions and absorbing pepsin, prevents further damage of pepsin to gastric mucosa when gastric mucosa fails, and selectively absorbs cholic acid and hemolytic soft phospholipids, which plays a certain role in gastric ulcer caused by bile reflux.
CAS:66960-34-7
Molecular Formula:C29H40N6O6S
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Metkephamid; Metkefamide; Unii-Mnl20Fxh9Y; Mnl20Fxh9Y
Brief Introduction
Is a synthetic opioid pentapeptide and derivative of [Met]enkephalin with the amino acid sequence Tyr-D-Ala-Gly-Phe-(N-Me)-Met-NH2. It behaves as a potent agonist of the δ- and μ-opioid receptors with roughly equipotent affinity, and also has similarly high affinity as well as subtype-selectivity for the κ3-opioid receptor.
Despite its peptidic nature, upon systemic administration, metkefamide rapidly penetrates the blood-brain-barrier and disperses into the central nervous system where it produces potent, centrally-mediated analgesic effects, of which have been shown to be dependent on activity at both the μ- and δ-opioid receptors. In addition, on account of modifications to the N- and C-terminals, metkefamide is highly stable against proteolytic degradation relative to many other opioid peptides. As an example, while its parent peptide, [Met]enkephalin, has an in vivo half-life of merely seconds, metkefamide has a half-life of nearly 60 minutes, and upon intramuscular administration, has been shown to provide pain relief that lasts for hours.
Likely on account of its δ-opioid activity, clinical trials have found metkefamide to possess less of a tendency for producing many of the undesirable side effects usually associated with conventional opioids such as respiratory depression, tolerance, and physical dependence. However, it has been shown to cause some additional side effects that are considered unusual for standard opioid analgesics like sensations of heaviness in the extremities and nasal congestion—though these were not considered to be particularly distressing—and it has also been shown to raise the seizure threshold in animals. In any case, clinical development was not further pursued after phase I clinical studies and metkefamide never reached the pharmaceutical market.
CAS:66960-35-8
Molecular Formula:C31H44N6O8S
Brief Introduction
The molecular formula of MetkephaMide acetate is C31H44N6O8S.
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