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Sichuan Neijiang Huixin Pharmaceutical Co., Ltd.

23 YRS

Sichuan, China

CNY 3 Million

53280 m²

Less than 50 people

Main Products: Vitamin D2 / Ergosterol / Vitamin D3 / Calcipotriene / Calcitriol / Alfacalcidol

Sichuan, China

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Calcipotriene / CAS 112828-00-9

OVERVIEW

Packaging

25 KG/Fibre Drum

Lead Time

14-30 days

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DESCRIPTION

Calcipotriol

IUPAC name:(1R,3S,5E)-5-{2-[(1R,3aS,4Z,7aR)-1-[(2R,3E)-5-cyclopropyl-5-hydroxypent-3-en-2-yl]-7a-methyl-octahydro-1H-inden-4-ylidene]ethylidene}-4-methylidenecyclohyytyexane-1,3-diol

Trade name: Daivobex; Dovobex; Sorilux

CAS No.:112965-21-6

Molecular Formula: C₂₇H₄₀O₃

Molar mass: 412.605

Pharmacology action:

This product is similar to vitamin D analogues, the pharmacodynamic properties and vitamin D3 active metabolite of Calcitriol. In several in vitro models of this product and Calcitriol significantly inhibit cell proliferation and stimulate cell differentiation, such as both reduce the number of cells, total DNA content and radiation labeled thymidine incorporation into DNA, increase human keratinocytes and enhance the activity of the protein cross-linking enzyme, inhibit the proliferation and differentiation of epidermal cells.

Typical Properties

Calcipotriol is a derivative of vitamin D, which combines with VD3 receptor on the cell surface and regulates the synthesis of DNA and keratin in cells. It can inhibit the excessive proliferation and induce the differentiation of skin cells (keratinocytes), so as to correct the abnormal proliferation and differentiation of psoriasis skin cells. At the same time, it can regulate the release of inflammatory factors, inhibit inflammatory infiltration and proliferation, and play an anti-inflammatory role. It has better therapeutic effect on psoriasis of scalp and other special parts.

CAS No.

112828-00-9

Formula

C27H40O3

Molecular Mass

412.60500

Exact Mass

412.29800

PSA

60.69000

Logp

5.09060

IUPAC

(1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(E,2R,5S)-5-cyclopropyl-5-hydroxypent-3-en-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol

SMILES

CC(C=CC(C1CC1)O)C2CCC3C2(CCCC3=CC=C4CC(CC(C4=C)O)O)C

Matter Classification

organic

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