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Antineoplastic Agents

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CAS:357166-29-1
Molecular Formula:C20H33N5Na2O13
Pemetrexed (Sodium Salt Hydrate); N-[4-[2-(2-Amino-4,7-Dihydro-4-Oxo-3H-Pyrrolo[2,3-D]Pyrimidin-5-Yl)Ethyl]Benzoyl]-L-Glutamic Acid Disodium Salt Hydrate; Pemetrexed Disodium 7-Hydrate; Pemetrexed Disodium 7H2O; Alimta; Pemetrexed Disodium Hepthydrate; Pemetrexed Disodium; Disodium;(2S)-2-[[4-[2-(2-Amino-4-oxo-1,7-Dihydropyrrolo[2,3-d]Pyrimidin-5-yl)Ethyl]Benzoyl]Amino]Pentanedioate;Heptahydrate
Brief Introduction
Pemetrexed Disodium Heptahydrate is an chemotherapy drug for the treatment of pleural mesothelioma and non-small cell lung cancer. Pemetrexed Disodium Heptahydrate exhibit inhibitory activities towards thymidylate synthase as well as other folate dependent enzymes.
CAS:4291-63-8
Molecular Formula:C10H12ClN5O3
2-Chloro-2'-Deoxyadenosine; 2-Cda; 2Cda; 2-Chloro-2′-Deoxyadenosine; 2-Chloro-9-(2-Deoxy-β-D-Arabinofuranosyl)Adenine; 2-Cl-Dado; Cda; Cladrivine
Brief Introduction
Cladribine is a purine analogue and antineoplastic agent used primarily in the therapy of hairy cell leukemia. Cladribine is typically given intravenously daily for 7 days, usually as a single course, and has not been associated with serum enzyme elevations during therapy or with instances of clinically apparent acute liver injury with jaundice. Cladribine is 2'-Deoxyadenosine in which the hydrogen at position 2 on the purine ring has been substituted by chlorine. It inhibits the synthesis and repair of DNA, particularly in lymphocytes and monocytes, and is used as an antimetabolite antineoplastic drug for the treatment of lymphoid malignancies including hairy-cell leukaemia and chronic lymphocytic leukaemia. It has a role as an antineoplastic agent and an immunosuppressive agent. It is a purine 2'-deoxyribonucleoside and an organochlorine compound.
CAS:50-07-7
Molecular Formula:C15H18N4O5
Mitomycin C; ((1As,8S,8Ar,8Bs)-6-Amino-8A-Methoxy-5-Methyl-4,7-Dioxo-1,1A,2,4,7,8,8A,8B-Octahydroazirino[2',3':3,4]Pyrrolo[1,2-A]Indol-8-Yl)Methyl Carbamate; Ametycine; Mitomycin C(Ametycine)
Brief Introduction
Mitomycin is a methylazirinopyrroloindoledione antineoplastic antibiotic isolated from the bacterium Streptomyces caespitosus and other Streptomyces bacterial species. Bioreduced mitomycin C generates oxygen radicals, alkylates DNA, and produces interstrand DNA cross-links, thereby inhibiting DNA synthesis. Preferentially toxic to hypoxic cells, mitomycin C also inhibits RNA and protein synthesis at high concentrations.
CAS:51-20-7
Molecular Formula:C4H3BrN2O2
5-Br-Uracil; 5-Bromo-Uraci; 5-Brura; 5-Bromo-2,4-Dioxopyrimidine; 5-Bromo-2,4(1H,3H)-Pyrimidinedione; 5-Bromo-2,4-Dihydroxypyrimidine; 5-Bromo-2,3-Dihydroxypyrimidine; 5-Bromo-1H-Pyrimidine-2,4-Dione
Brief Introduction
5-Bromouracill is a pyrimidine analogue, which is mainly used in the treatment of tumors. 5-fluorouracil is one of the antimetabolic drugs. Xenon difluoride reacts with uracil to produce 5-fluorouracil.
CAS:1820-81-1
Molecular Formula:C4H3ClN2O2
2,4(1H,3H)-Pyrimidinedione,5-Chloro-; 2,4-Pyrimidinediol,5-Chloro-; 3H)-Pyrimidinedione,5-Chloro-4(1H; 5-Chloro-1,2,3,4-Tetrahydropyrimidine-2,4-Dione; 5-Chloropyrimidine-2,4-Diol
Brief Introduction
Used for the experimental and clinical treatment of neoplastic and viral diseases.
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