Omapatrilat (INN) is a novel antihypertensive agent that inhibits both neutral endopeptidase (NEP) and angiotensin converting enzyme. NEP inhibition results in elevated natriuretic peptide levels, promoting natriuresis, diuresis, vasodilation, and reductions in preload and ventricular remodeling. This drug from Bristol-Myers Squibb was not approved by the U.S. Food and Drug Administration due to angioedema safety concerns. Omapatrilat angioedema was attributed to its dual mechanism of action, inhibiting both angiotensin converting enzyme (ACE), and neutral endopeptidase, both of these enzymes are responsible for the metabolism of bradykinin which causes vasodilation, angioedema, and airway obstruction.

Ornidazole

CAS:16773-42-5

Molecular Formula:C7H10ClN3O3

Alias

More Information

1-(3-Chloro-2-Hydroxypropyl)-2-Methyl-5-Nitroimidazole; 1-Chloro-3-(2-Methyl-5-Nitro-1H-Imidazol-1-Yl)-2-Propanol; 1-Chloro-3-(2-Methyl-5-Nitro-1H-Imidazol-1-Yl)Propan-2-Ol; 1-Chloro-3-(2-Methyl-5-Nitroimidazol-1-Yl)Propan-2-Ol; Ornidazol A-(Chloromethyl)-2-Methyl-5-Nitro-1H-Imidazole-1-Ethanol; Alpha-(Chlormethyl)-2-Methyl-5-Nitro-Imidazol-1-Aethanol; Alpha-(Chloromethyl)-2-Methyl-5-Nitro-1H-Imidazole-1-Ethano; Ro7-0207

Brief Introduction

Ornidazole is the third generation of nitroimidazole, which has obvious antibacterial advantages over metronidazole and Tinidazole. The half-life of plasma elimination of ornidazole is 14.4 hours, which is higher than that of metronidazole (8.4 hours) and Tinidazole (12.7 hours). Therefore, ornidazole can reduce the times of taking medicine and is more convenient to use. It acts on the DNA of anaerobes, amoebas, Giardia and Trichomonas cells to break their helix structure or prevent their transcription and replication, resulting in the death of pathogenic bacteria. The peak plasma concentration was reached 2 hours after oral administration, and the bioavailability was about 90%.

N-[[2-Methoxy-5-[5-(Trifluoromethyl)Tetrazol-1-Yl]Phenyl]Methyl]-2-Phenylpiperidin-3-Amine

CAS:168266-90-8

Molecular Formula:C21H23F3N6O

Brief Introduction

Vofopitant (GR-205,171) is a drug which acts as an NK1 receptor antagonist. It has antiemetic effects as with other NK1 antagonists, and also shows anxiolytic actions in animals. It was trialled for applications such as the treatment of social phobia and post-traumatic stress disorder, but did not prove sufficiently effective to be marketed.

2,4-Dimethylcinnamic Acid

CAS:1685-80-9

Molecular Formula:C11H12O2

Alias

More Information

(2E)-3-(2,4-Dimethylphenyl)Acrylic Acid; 3-(2,4-Dimethylphenyl)Acrylic Acid; (E)-3-(2,4-Dimethylphenyl)Prop-2-Enoic Acid; 3-(2,4-Dimethylphenyl)Prop-2-Enoic Acid; 2-Propenoic Acid, 3-(2,4-Dimethylphenyl)-

Brief Introduction

This product is an organic synthetic intermediate and can be used as a pharmaceutical intermediate.

3,5-Dimethoxycinnamic Acid

CAS:16909-11-8

Molecular Formula:C11H12O4

Alias

More Information

Imethoxycinnamic Acid; 3-(3,5-Dimethoxyphenyl)Acrylic Acid; 3,5-Dimethoxy Cinnamic Acid; 3-(3,5-Dimethoxyphenyl)Propenoic Acid

Brief Introduction

This product is an organic acid, which can be used as pharmaceutical raw materials and intermediates.

Inquiry (

/ 10

)

Clear All