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CAS:168266-90-8
Molecular Formula:C21H23F3N6O
Brief Introduction
Vofopitant (GR-205,171) is a drug which acts as an NK1 receptor antagonist. It has antiemetic effects as with other NK1 antagonists, and also shows anxiolytic actions in animals. It was trialled for applications such as the treatment of social phobia and post-traumatic stress disorder, but did not prove sufficiently effective to be marketed.
CAS:1685-80-9
Molecular Formula:C11H12O2
Alias
More Information
(2E)-3-(2,4-Dimethylphenyl)Acrylic Acid; 3-(2,4-Dimethylphenyl)Acrylic Acid; (E)-3-(2,4-Dimethylphenyl)Prop-2-Enoic Acid; 3-(2,4-Dimethylphenyl)Prop-2-Enoic Acid; 2-Propenoic Acid, 3-(2,4-Dimethylphenyl)-
Brief Introduction
This product is an organic synthetic intermediate and can be used as a pharmaceutical intermediate.
CAS:16909-11-8
Molecular Formula:C11H12O4
Alias
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Imethoxycinnamic Acid; 3-(3,5-Dimethoxyphenyl)Acrylic Acid; 3,5-Dimethoxy Cinnamic Acid; 3-(3,5-Dimethoxyphenyl)Propenoic Acid
Brief Introduction
This product is an organic acid, which can be used as pharmaceutical raw materials and intermediates.
CAS:16985-03-8
Molecular Formula:C25H33NO2
Alias
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2-Methyl-4-<Pyridyl-(4)>-5-Hydroxy-6-<3-Methyloctyl-(2)>-2H-Chromenyl-(2)-Oxymagnesiumbromid; Nonabino; 2,2-Dimethyl-7-(3-Methyloctan-2-Yl)-4-(Pyridin-4-Yl)-2H-Chromen-5-Ol; 7-(1,2-Dimethyl-Heptyl)-2,2-Dimethyl-4-Pyridin-4-Yl-2H-Chromen-5-Ol; Nonabinum [Inn-Latin]; 2,2-Dimethyl-7-(3-Methyl-2-Octyl)-4-(4-Pyridyl)-2H-Chromen-5-Ol; 2,2-Dimethyl-5-Hydroxy-7-(3-Methyl-2-Octyl)-4-(4-Pyridyl)-2H-1-Benzopyran; Nonabine; Nonabinum; Nonabino [Inn-Spanish]; Unii-77Duk856J7; Brl-4664; 77Duk856J7
Brief Introduction
Nonabine (BRL-4664) is a drug which is a cannabinoid derivative, which was developed for the prevention of nausea and vomiting associated with cancer chemotherapy. It has strong antiemetic effects equivalent to those of chlorpromazine, and also produces some mild sedative effects, along with dry mouth and EEG changes typical of cannabinoid agonists, but with minimal changes in mood or perception, suggesting the abuse potential is likely to be low.
CAS:170098-38-1
Molecular Formula:C25H36N2O6
Alias
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Alvimopan Dihydrate; 2-[[(2S)-2-Benzyl-3-[(3R,4R)-4-(3-Hydroxyphenyl)-3,4-Dimethyl-1-Piperi dyl]Propanoyl]Amino]Acetic acid Dihydrate; (((2S)-2-(((3R,4R)-4-(3-Hydroxyphenyl)-3,4-Dimethylpiperidin-1-yl)Methyl)-3-Phenylpropanoyl)Amino)Acetic acid Dihydrate; Glycine, N-((2S)-2-(((3R,4R)-4-(3-Hydroxyphenyl)-3,4-Dimethyl-1-Piperidinyl)Methyl)-1-oxo-3-Phenylpropyl)-, Dihydrate; Glycine, N-(2-((4-(3-Hydroxyphenyl)-3,4-Dimethyl-1-Piperidinyl)Methyl)-1-oxo-3-Phenylpropyl)-, Dihydrate, (3R-(1(S*),3Alpha,4Alpha))-; Glycine, N-(2-((4-(3-Hydroxyphenyl)-3,4-Dimethyl-1-Piperidinyl)Methyl)-1-oxo-3-Phenylpropyl)-,Dihydrate, (3R-(1(S*),3-Alpha,4-Alpha))-; (2S, 3R, 4R)[[2-[[4-(3-Hydroxyphenyl)-3,4-Dimethyl-1-Piperidinyl ]Methyl]-1-oxo-3-Phenylpropyl]-Amino]Acetic acid Dihydrate; 2-[(2S)-2-Benzyl-3-[(3R,4R)-4-(3-Hydroxyphenyl)-3,4-Dimethylpiperidin-1-yl]Propanamido]Acetic acid Dihydrate
Brief Introduction
2-[[(2S)-2-Benzyl-3-[(3R,4R)-4-(3-Hydroxyphenyl)-3,4-Dimethylpiperidin-1-Yl]Propanoyl]Amino]Acetic Acid,Dihydrate (ly 246736; ADL 8-2698) is a novel oral peripheral opioid receptor (pam-or) antagonist with an IC50 of 1.7 nm.
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