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2,4-Dihydroxypyrimidine; 4-Hydroxy-2(1H)-Pyrimidinone; 4-Pyrimidinol; 4-Pyrimidone; 4H-Pyrimidin-2-one; Beta-Uracil; NSC 767; Uracil-4-ol; 2,4(1H,3H)-Pyrimidinedione; 2,4-Dioxo-3,4-Dihydropyrimidin; Urasil; 1H-Pyrimidine-2,4-Dione; 2,4-Pyrimidinediol
Brief Introduction
Uracil is an organic base, one of the four main bases in RNA, a major pyrimidine component in RNA, and also a component of various uridine acids. The triphosphate compound of uridine is urine triphosphate, which is the precursor of uracil in the process of ribonucleic acid biosynthesis. Urine triphosphate as coenzyme participates in the synthesis of some sugar biochemical books.
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CAS:75607-67-9
Molecular Formula:C10H13FN5O7P
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9-Beta-D-Arabinofuranosyl-2-Fluoroadenine5’-Monophosphate; Fludarabinemonophosphate; 9-Beta-D-Arabinofuranosyl-2-Fluoroadenine-5'-Dihydrogen Phosphate; Fludarabine(NSC-118218)Phosphate; 2-Fluoro-9-(5-o-Phosphono-beta-d-Arabinofuranosyl)-9h-Purin-6-Amine; 2-Fluoro-Araamp;9-beta-Arabinofuranosyl-2-Fluoroadchemicalbookenine-5’-Phosphate; 5-Monophosphate
Brief Introduction
It has a role as an antimetabolite, an antineoplastic agent, an immunosuppressive agent, an antiviral agent, a prodrug and a DNA synthesis inhibitor.
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CAS:85622-93-1
Molecular Formula:C6H6N6O2
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Temodar; 4-Methyl-5-Oxo-2,3,4,6,8-Pentazabicyclo[4.3.0]Nona-2,7,9-Triene-9-Carboxamide; Methazolastone; 3,4-Dihydro-3-Methyl-4-Oxoimidazo[5,1-D]-1,2,3,5-Tetrazin-4(3H)-One; TMZ
Brief Introduction
Temozolomide is the first oral effective imidazo tetrazine antitumor drug. It belongs to the second generation alkylating agent with antitumor activity. It does not need intrahepatic metabolic activation after oral administration. It is characterized by easy penetration through the blood-brain barrier, good tolerance and no superimposed toxicity with other drugs. It has synergistic effect with radiotherapy. It is suitable for malignant gliomas that relapse after routine treatment, For example, glioblastoma multiforme or degenerative astrocytoma is also the first-line drug for the treatment of metastatic melanoma.
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CAS:107007-99-8
Molecular Formula:C18H25ClN4O
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1-Methyl-N-[(3-Endo)-9-Methyl-9-Azabicyclo[3.3.1]Non-3-Yl]-1H-Indazole-3-Carboxamide; 1-Methyl-N-[(1S,5R)-9-Methyl-9-Azabicyclo[3.3.1]Nonan-3-Yl]Indazole-3-Carboxamide,Hydrochloride; 1-Methyl-N-(9-Methyl-9-Azabicyclo(3.3.1)Non-3-Yl)-1H-Indazole-3-Carboxamid; Endo-Monohydrochlorid; 1-Methylindazole-3-Carboxylic acid; Midehydrochloride; 1-Methyl-N-[(3-Endo)-9-Methyl-9-Azabicyclo[3.3.1]Non-3-Yl]-1H-Indazole-3-Carboxamide Hydrochloride; 1-Methyl-N-(9-Methyl-9-Azabicyclo[3.3.1]Nonan-3-Yl)-1H-Isoindole-3-Carboxamide Hydrochloride
Brief Introduction
Granisetron hydrochloride is a highly selective 5-HT3 receptor antagonist, which has good preventive and therapeutic effects on nausea and vomiting caused by radiotherapy, chemotherapy and surgery. Radiotherapy, chemotherapy and surgery can cause the release of 5-HT from the intestinal chromaffin cells. 5-HT can activate the 5-HT3 receptor of the central or vagus nerve and cause vomiting reflex. The mechanism of controlling nausea and vomiting is to inhibit the occurrence of nausea and vomiting by antagonizing 5-HT3 receptors in central chemosensory area and peripheral vagus nerve endings. It has high selectivity and no side effects such as extrapyramidal reaction and excessive sedation.
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CAS:122111-03-9
Molecular Formula:C9H12ClF2N3O4
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2'-Deoxy-2',2'-Difluorocytidine; Gemcitabine Hcl(Tabines); 2’,2’-Difluorodeoxycytidinemonohydrochloride; 2’-Deoxy-2’,2’-Difluorocytidinemonohydrochloride; 2’-Deoxy-2’,2’-Difluoro-Cytidinmonohydrochloride; Gemzar; Ly188011; Ly188011 Hydrochloride; 2',2'-Difluoro-2'-Deoxycytidine
Brief Introduction
Gemcitabine hydrochloride is a synthetic new type of two fluoronucleoside antitumor drug developed by Eli Lilly. It was approved in 1995 in South Africa, Sweden, Holland, Australia and other countries. In 1996, the US Food and Drug Administration approved the first line treatment for non-small cell lung cancer and pancreatic cancer. Gemcitabine hydrochloride, a nucleoside homologue, is a cell cycle specific antitumor drug. It mainly kills cells in S phase (DNA synthesis) and blocks the transition of cell proliferation from G1 to S phase. Gemcitabine is suitable for the treatment of advanced or metastatic pancreatic cancer and locally advanced or metastatic non-small cell lung cancer, advanced and non-small cell lung cancer, pancreatic cancer, bladder cancer, breast cancer and other solid tumors.
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